2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

Related Products

PDF 1.35 MB

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101392S2
    Harmane-d4
    		Inhibitor
    Harmane-d4 is deuterium-labeled Harmane (HY-101392).
    Harmane-d<sub>4</sub>
  • HY-N2697
    6-Acetonyl-N-methyldihydrodecarine
    		Inhibitor
    6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases.
    6-Acetonyl-N-methyldihydrodecarine
  • HY-105041
    Tedizolid phosphate sodium
    		Inhibitor
    Tedizolid phosphate (TR-701FA) sodium is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria.
    Tedizolid phosphate sodium
  • HY-14605R
    Rasagiline mesylate (Standard)
    		Inhibitor
    Rasagiline (mesylate) (Standard) is the analytical standard of Rasagiline (mesylate). This product is intended for research and analytical applications. Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Rasagiline mesylate (Standard)
  • HY-B0534R
    Moclobemide (Standard)
    		Inhibitor
    Moclobemide (Standard) is the analytical standard of Moclobemide. This product is intended for research and analytical applications. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
    Moclobemide (Standard)
  • HY-111156
    NW-1172 free base
    		Inhibitor
    NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.
    NW-1172 free base
  • HY-W725928
    DOPR hydrochloride
    		Activator
    DOPR hydrochloride is an amphetamine with hallucinogenic properties.
    DOPR hydrochloride
  • HY-123665
    PSB-1410
    		Inhibitor 99.22%
    PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC50 for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively.
    PSB-1410
  • HY-123556
    SZV-558
    		Inhibitor
    SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.
    SZV-558
  • HY-175723
    MAO-A/B-IN-4
    		Inhibitor
    MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections.
    MAO-A/B-IN-4
  • HY-W415287
    DL-Thyroxine
    		Inhibitor
    DL-Thyroxine, a thyroid hormone, is a monoamine oxidase inhibitor.
    DL-Thyroxine
  • HY-B0884AR
    Minaprine dihydrochloride (Standard)
    		Inhibitor
    Minaprine (dihydrochloride) (Standard) is the analytical standard of Minaprine (dihydrochloride). This product is intended for research and analytical applications. 0
    Minaprine dihydrochloride (Standard)
  • HY-B1111R
    Amitraz (Standard)
    		Inhibitor
    Amitraz (Standard) is the analytical standard of Amitraz. This product is intended for research and analytical applications. Amitraz is a non-systemic acaricide and insecticide with alpha-adrenergic agonist activity that interacts with octopamine receptors in the central nervous system and inhibits monoamine oxidase and prostaglandin synthesis.
    Amitraz (Standard)
  • HY-14205
    NW-1772
    		Inhibitor
    NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases.
    NW-1772
  • HY-122128
    Lilly 51641
    		Inhibitor
    Lilly 51641 (LY-51641) is a selective and orally active Type A monoamine oxidase inhibitor. Lilly 51641 has the potential for the research of depressed and schizophrenic.
    Lilly 51641
  • HY-157392
    hMAO-A-IN-1
    		Inhibitor
    hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC50 of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression.
    hMAO-A-IN-1
  • HY-59059
    5-(2-Aminopropyl)indole
    		Inhibitor
    5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.
    5-(2-Aminopropyl)indole
  • HY-70057R
    Safinamide (Standard)
    		Inhibitor
    Safinamide (Standard) is the analytical standard of Safinamide. This product is intended for research and analytical applications. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
    Safinamide (Standard)
  • HY-105127
    Brofaromine hydrochloride
    		Inhibitor
    Brofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.
    Brofaromine hydrochloride
  • HY-164649
    Atibeprone
    		Inhibitor
    Atibeprone (Lu 53439) is a selective MAO-B inhibitor. Atibeprone has antidepressant activity.
    Atibeprone
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.